This chapter provides a comprehensive review of both the preoperative and operative considerations given toward proper suture selection and technique. Proper suturing technique is essential during the repair of surgical defects to prevent postoperative complications and to maximize wound healing and cosmetic outcomes. Deep dermal sutures, interrupted buried dermal suture, buried vertical mattress suture, buried butterfly suture, pulley sutures, epidermal sutures, and running epidermal sutures are various types of suture techniques, which are also provided in this chapter. Loading the needle, handling the needle and suture, handling the tissue, and the simple instrument tie are other important topics of this chapter, which are also discussed. 18 well-colored figures are also presented in this chapter.