This chapter briefly presents structural and embryological aspects of skin and its appendages. Skin is the largest organ of body and it ensheaths all other organs. It plays a major role in defense, synthesis, homeostasis and aesthetics. Dermatosurgery and aesthetic surgery deal with the surgical aspects of skin and its appendages. Skin is made up of three layers, namely epidermis, dermis and hypodermis or subcutis. It consists of cells, connective tissues and special appendages which are derived from ectoderm, neuroectoderm and mesoderm. Epidermis is the outermost layer of the skin and is composed of stratified squamous epithelium. The epidermis is mainly composed of keratinocytes (80%). The dermis is composed of two layers, namely the superficial papillary dermis and the deeper reticular dermis. Another important component of the dermis is the ground substance, an amorphous material that fills spaces between the fibrillar and cellular components of the dermis, imparting turgidity and resilience. A brief description on the blood and lymphatic vessels, and nerve supply has been provided in this chapter.