This chapter mainly focuses on the setting up a dermatosurgery unit. Dermatologists are increasingly performing cutaneous surgery. The surgeries performed range from simple procedures like electrosurgery, biopsies, chemical cauteries, sclerotherapy, soft tissue augmentation, botulinum toxin chemodenervation to more aggressive surgeries such as vitiligo surgery, nail surgeries and more complex labor intensive procedures like hair restoration, liposuction, etc. Since patient’s safety is the first concern, it is not only the dermatologist skill which matters but also the infrastructure. A well-equipped, well-designed surgical suite improves the experience for both patients and the dermatologist. This chapter explains about the nomenclature, requirements of a dermatosurgery unit, the dermatosurgery unit types, location of the dermatosurgery unit in the office or hospital and advance cardiovascular life support. Operation room records, operation theater fumigation and/or surface disinfection, waste disposal and ergonomics are also discussed in this chapter.