This chapter reviews published studies on surgical management of non-vitiligo leukoderma. Non-vitiligo leukoderma makes an important spectrum of hypopigmented disorders most of them are responsive to surgical intervention. However, there seems to be lack of awareness among patients and physicians about the possible ways of intervention. This has led to lack of sufficient literature supporting the therapeutic options. Non-vitiligo leukodermas form an important spectrum of hypopigmented disorders; treatment with surgical modalities should be better studied in the management of these patients. A detailed discussion on the surgical treatment modalities of non-vitiligo leukodermas, indications of non-vitiligo leukodermas has been provided in this chapter. Four well-illustrated tables and five well-colored figures are also presented in this chapter.