Thromboelastography is used to assess viscoelastic changes in clotting whole blood under low shear conditions after adding a specific coagulation activator. The TEG, ROTEM, and Sonoclot analysis are point of care (POC) coagulation monitoring devices which assess the viscoelastic properties of whole blood. They measure the entire clotting process, at the bedside in a sample of whole blood. Rotational thromboelastometry, ROTEM, is also a vPOC test with a modified instrument similar to TEG. In ROTEM, the cup containing the blood is stationary and the pin rotates. This provides increased resistance to vibrations. The ROTEM uses an automated pipetting system and provides faster results when compared to TEG. Using TEG/ROTEM in goal-orientated algorithms, clinicians may be able to optimize targeted transfusion therapies with specific coagulation factors instead of empirically administering multiple components with potentially hazardous effects, especially in trauma, cardiovascular surgery, and LT.