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Chapter-35 Platelet Function Testing and Newer Perioperative Anticoagulant Monitoring

BOOK TITLE: Monitoring in Anesthesia and Critical Care

Author
1. Agarwal Anil
ISBN
9789352700431
DOI
10.5005/jp/books/18044_36
Edition
1/e
Publishing Year
2018
Pages
10
Author Affiliations
1. Chacha Nehru Bal Chikitsalya, Geeta Colony, Delhi, 131, Ankur Apartment, 7, IP Extension, Parparganj, New Delhi, Chacha Nehru Bal Chikitsalaya, Delhi, India, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, India, All India Institute of Medical Sciences, New Delhi, India, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India, Fortis Hospital, Noida, Uttar Pradesh, India
Chapter keywords
Platelet function test, anticoagulant monitoring, platelet aggregation, light transmission aggregometry, platelet function analyzer, monitoring heparin therapy, fondaparinux therapy

Abstract

This chapter is divided into two parts i.e. platelet function testing and newer perioperative anticoagulant monitoring. This chapter mainly focuses on the different available platelet function tests. Human platelets play a crucial role in primary hemostasis. However, in addition to the key role in primary hemostasis, platelets also contribute greatly to vessel repair, inflammation, tumor growth, and in the promotion of atherosclerosis. Point of care platelet function tests and newer anticoagulant assays are of immense help to the anesthesiologists and intensivists for perioperative decision making and judicious transfusion management in different clinical settings like cardiac surgery, PCI, trauma, obstetric hemorrhage, liver transplantation, neuroendovascular procedures, etc. Rigorous quality control is essential to maintain the reliability of these newer assays and should be carefully implemented in centers using these assays perioperatively. Tests based on platelet aggregation, test based on platelet adhesion—platelet function analyzer-100, platelet function tests combined with viscoelastic global coagulation assays, monitoring warfarin therapy: point of care international normalized ratio assays, etc. are some other important topics also covered in this chapter.

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