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Chapter-10 Adjuvant Treatments in Low Ovarian Response

BOOK TITLE: Handbook of Ovarian Stimulation

Author
1. Guillén Alfredo
ISBN
9789352700608
DOI
10.5005/jp/books/14200_11
Edition
1/e
Publishing Year
2018
Pages
12
Author Affiliations
1. Madrid, Spain, IVI Madrid, Madrid, Spain
Chapter keywords
Hypothalamus-pituitary axis, low ovarian reserve, androgenization, aromatase inhibitor, letrozole, dehydroepiandrosterone, transdermal testosterone, growth hormone

Abstract

The management of patients with low ovarian reserve is one of the most important challenges in every day practice in the infertility clinic. Different treatment options for low ovarian reserve are androgenization, aromatase inhibitor—letrozole, dehydroepiandrosterone, transdermal testosterone, and growth hormone. The use of androgenization approaches with letrozol, DHEA, and transdermal testosterone lack of robust data showing an improvement in live birth rates in women with poor ovarian response. Data for the use of transdermal testosterone in a recent meta-analysis showed an increase in live birth rate. The use of growth hormone is conditioned by the cost of this alternative, but a review showed a more favourable result in live birth rate.

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