“Freeze-all” concept in assisted reproductive technology (ART) appears as a consequence of great advancements in the vitrification protocols allowing us to “electively” defer an embryo transfer from a fresh to a frozen cycle. It represents an opportunity to provide a more natural environment for the embryo. The chapter covers factors in ART contributing to the freeze-all policy that include vitrification as a safe technique, implementation of ovarian hyperstimulation syndrome-free clinics, rise in genetic screening, and concern on perinatal and obstetric outcomes. Evidence in favor of freeze-all concept is also discussed in this chapter that quotes a recent meta-analysis that concluded that the use of frozen embryo transfer, compared with fresh embryo transfer, significantly improves clinical and ongoing pregnancy rates in patients submitted to ART. As of today, the benefits of the freeze-all policy are based mainly on high responder patients and they cannot be extrapolated to the general in vitro fertilization population. The major advantage or strength of a freeze-all strategy is the potential for eliminating ovarian hyperstimulation syndrome.