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Chapter-03 Stimulation Protocols for Intrauterine Insemination

BOOK TITLE: Handbook of Ovarian Stimulation

Author
1. Hinduja Ritu
2. Shrimali Kalyani
ISBN
9789352700608
DOI
10.5005/jp/books/14200_4
Edition
1/e
Publishing Year
2018
Pages
9
Author Affiliations
1. Rotunda—The Center for Human Reproduction, Mumbai, Maharashtra, India, Nova IVI Fertility, Mumbai, Maharashtra, India, Nova IVF Fertility, Mumbai, Maharashtra, India; Managing Committee, Indian, Society of Assisted Reproduction, Nova IVF Fertility Center, Mumbai, Maharashtra, India, Nova IVF Fertility, Mumbai, Maharashtra, India; Managing Committee, Indian Society of Assisted Reproduction; Managing Committee, Maharashtra Chapter of Indian Society of Assisted Reproduction, NOVA IVF Fertility, Mumbai, Maharashtra, India
2. Indian College of Obstetricians &, Gynaecologists (ICOG), Mumbai, Maharashtra, India; Nova IVI Fertility, Indore, Madhya Pradesh, India, Nova IVI Fertility, Indore, Madhya Pradesh; Indian College of Obstetricians and Gynaecologists (ICOG), Mumbai, Maharashtra, India, Nova IVI Fertility, Indore, Madhya Pradesh
Chapter keywords
Intrauterine insemination, ovarian stimulation, clomiphene citrate, letrozole, gonadotropin, multiple pregnancy, ovarian hyperstimulation syndrome, selective estrogen, receptor modulator, estrogen production, aromatase inhibitor, tamoxifen citrate

Abstract

Intrauterine insemination (IUI) is one of the first treatment options for infertility and a technique in assisted reproductive technologies (ART). It is the safest, least invasive, and cost-effective forms of assisted reproduction. Ovarian stimulation has been shown to significantly improve the outcome in IUI cycles. Many oral agents are also used for ovarian stimulation. Clomiphene citrate is an effective treatment for oligoovulation and anovulation. Gonadotropins are used to treat infertility caused by anovulation. Letrozole, helpful in ovulation induction, has been shown to be superior to clomiphene for patients with polycystic ovarian syndrome. Protocols should attempt to minimize risk of multiple pregnancy and ovarian hyperstimulation syndrome.

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