The chapter talks about the medical and surgical nursing. It covers a range of topics that include health and wellness care, nursing process, wound healing and wound care, disruption of homeostasis, cardiovascular disorders, hematologic disorders, respiratory disorders, gastrointestinal disorders, renal and urinary tract disorders, reproductive system disorders, immune system disorders, eye, ear and nose disorders. The nursing process provides a basis for problem-solving, clinical decisions and individualized patient care. It uses the scientific method of observation, measurement, data collection and data analysis to evaluate the needs of patients and their families. This chapter also delves upon nurse practice acts, legal concepts of responsibility, possible defenses to a health care negligence suit, professional liability insurance for nurses, ethical aspects of nursing, common legal concerns for nurses and many others.