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Chapter-11 Clinical Implications of DNA Fragmentation Test

BOOK TITLE: ISARCON 2017 Manual of Data Management and Quality Control, March to Perfection Complete Hands of IVF

Author

1. Shrikhande Laxmi

ISBN

9789352700790

DOI

10.5005/jp/books/14173_12

Edition

1/e

Publishing Year

2018

Pages

Author Affiliations

1. Rhrikhanda Nursing Home, Nagpur, Shrikhande Laser and Endoscopy Center, 528 Hanuman Nagar, Manewada Road Nagpur (MS), India, AIDS Committee FOGSI, Nagpur, Maharashtra, Nagpur, Shrikhande Laser and Endoscopy Center, Nagpur, HIV/AIDS Committee-FOGSI, Shrikhande Laser and Endoscopy Center, 528 Hanuman Nagar, Manewada Road, Nagpur, Maharashtra, India, Shrikhande IVF and Surrogacy Centre, Nagpur, Maharashtra, India; FOGSI 2012, Shrikhande IVF and Surrogacy Center, Nagpur, Maharashtra, India, Shrikhande IVF and Surrogacy Centre Nagpur, Maharashtra, India, Shrikhande IVF and Surrogacy Centre, Nagpur, Maharashtra, India, Shrikhande Fertility clinic, Shrikhande Hospital and Research Centre Pvt Ltd, Nagpur, Maharashtra, India, Shrikhande Hospital and Research Centre, Nagpur, Maharashtra, India, Shrikhande Hospital and Research Centre Pvt Ltd, Nagpur, Maharashtra, India

Chapter keywords

Spermatozoa, DNA fragmentation, sperm DNA test, DNA fragmentation test, sperm chromatin structure assay, terminal transferase dUTP nick end labeling assay, TUNEL assay, sperm chromatin dispersion test, halo test, comet assay, sperm DNA damage

Abstract

Abstract

For a sperm DNA test to be clinically useful, it must have strong predictive capacity for pregnancy with little overlap between fertile and infertile samples. The four common tests used today are the sperm chromatin structure assay, the terminal transferase dUTP nick end labeling (TUNEL) assay, the sperm chromatin dispersion or halo test and the comet assay. Sperm DNA tests are all different and measure different aspects of DNA damage and have different sensitivities. Other topics discussed in the chapter are problems with DNA fragmentation test and why it should not be done, limitations and benefits of sperm DNA testing, and current concept about DNA test.

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