A quality policy is a predetermined course of action established as a guide toward accepted objectives and strategies of the organization. The policies should be a reflection of organization’s mission and objectives. A standard operating procedure (SOP) is a set of step-by-step instructions compiled by an organization to help workers carry out routine operations. The procedure of writing, revising, approving of SOPs and control of distribution of SOPs is an important quality assurance procedure. For in vitro fertilization (IVF) laboratory, SOPs are based on ISO 15189:2012 section 5.5. IVF lab director is responsible for the SOP preparation, implementation and review. The chapter also covers steps of writing SOPs, elements, aims, format of SOPs, etc.