The assisted reproductive technology (ART) laboratory has unique requirements for data management. There is also quality control (QC) and quality assurance (QA) tests that need to be done at specified times with the results constantly being monitored by the laboratory staff. The challenge for database developers is to program all these features in the background and create a user interface that is simple and intuitive. This chapter discusses the basic components of a database design and the special concerns for the ART laboratory. It lists key terminology for discussions with developers, essentials of data management, specific concerns for the ART laboratory, and current regulatory issues in order to better evaluate their current or future database solution.