Safety in histopathological laboratory is very important and is concerned with the various people working in it. Some of the basic safe working procedures which will ensure safety in histopathology laboratory are staff training, basic organization and common sense, equipment hazards, practical safety in routine use, and first aid action in reagent accidents. Staff training is the most important way to avoid accidents in histopathology laboratory is to give correct training to the staff working in it. In this chapter, questions for exercise and objective type questions are also provided.