Desquamative gingivitis is a generic term that may represent a variety of specific disease processes, but the clinical picture is indisputable. There may be threads or tags of loose necrotic epithelium, as the name suggests. Desquamative gingivitis involves not only marginal gingiva as do most cases of gingivitis but it also peels the attached gingiva often in a band-like fashion. The clinical description of desquamative gingivitis represents gingival manifestations of a variety of diseases. This chapter covers the classification, clinical features, histopathology, diagnosis, and therapy of desquamative gingivitis. Chronic desquamative gingivitis is the clinical manifestation of several different disorders, the clinical features are variable and diagnosis of the underlying condition is necessary for optimum management.