EXPORT CITATION

Chapter-10 Vaccines for Urinary Tract Infection

BOOK TITLE: Update on Urinary Tract Infections

Author
1. Arora Sohrab
2. Mallya Ashwin
ISBN
9789352701728
DOI
10.5005/jp/books/18034_11
Edition
1/e
Publishing Year
2018
Pages
10
Author Affiliations
1. Medanta—The Medicity, Gurgaon, Haryana, India, Medanta Kidney and Urology Institute, Medanta—The Medicity, Gurugram, Haryana, India, Michigan, USA, Vattikuti Urology Institute, Henry Ford Hospital
2. Fortis Escorts Hospital, New Delhi, India
Chapter keywords
Vaccine, urinary tract infection, urogenital colonization, heat-killed uropathogenic, vaginal vaccine Urovac, oral vaccine, UPEC

Abstract

Recurrent urinary tract infections (UTIs) are defined as at least three episodes of infection in one year, or at least two in 6 months. This problem is seen in approximately 20–30% of women with a UTI. Recurrent UTI can either be a relapse, or a reinfection. Daily or alternate day low dose antibiotic prophylaxis has been suggested for the management of reinfection. Other approaches include immediate short course of empiric antibiotics at the onset of symptoms, or as a postcoital antimicrobial prophylaxis. One alternate strategy for the prevention of recurrent and chronic UTIs is to develop mucosal or systemic UTI vaccines. The efforts toward discovering and testing novel vaccine candidates, adjuvants and delivery methods are promising, and there is hope for the future development of a vaccine to prevent UTI. The development of reverse vaccinology together with gene expression profiling, proteomic analyses, and emerging high-throughput genetic screens, promises to greatly increase the ability to identify useful vaccine targets.

Related Books

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved