Computed tomography (CT)-guided interventions may be divided into diagnostic intervention and therapeutic intervention. Typical diagnostic interventions are biopsies, which can be done as aspiration, or fine-needle biopsies, punch biopsies, or drill biopsies, depending on the area, accessibility, or the material that has to be biopsied. Aspiration or fine-needle biopsies are generally used to acquire liquid material (most commonly abscess) for a microbiological analysis. A large field of therapeutic intervention is pain management by the use of neurolysis or injection therapy of local anesthesia with or without corticoids. This chapter covers the desirable equipment, computed tomography-guided procedure, main risks and complications of computed tomography-guided interventions, and pitfalls. In this chapter, multiple choice questions are provided along with their answers.