This chapter describes patient preparation, positioning and contrast administration. The patient is positioned by the technologist on the specialized computed tomography (CT) table. The area of interest, for example chest, is positioned inside the CT gantry opening usually with the help of cross hair type positioning lights. This chapter covers the contrast, malignancy and acute pancreatitis, retrospective reconstruction, routine abdomen or pelvis, retroperitoneal hemorrhage (aka noncontrast abdomen/pelvis), trauma, computed tomography cystography, dual phase liver, triple phase liver, adrenal mass, renal infection, renal stone, computed tomography urography, pancreatic mass, and computed tomography enterography. In this chapter, multiple choice questions are provided along with their answers.