The chapter deals with management of patients with metabolic and endocrinal disorders like liver, jaundice, hepatitis, cirrhosis of liver, liver cancer, liver abscess, liver trauma, etc. It also details upon nursing care of patient with biliary disorders and exocrine pancreatic disorders. Endocrine system anatomy and physiology, diagnostic tests for the endocrine system, disorders related to antidiuretic hormone imbalance, pituitary tumors, disorders of the thyroid gland, disorders of the parathyroid glands, diabetes mellitus, and disorders of the adrenal glands are described with their management. Liver transplantation is the replacement of diseased liver by a healthy organ recovered from a recently brain dead individual or lobe is resected and implanted from live donor.