This chapter describes the drugs for cardiac failure, which include adrenaline, noradrenaline, and digoxin. Anaphylaxis and angioneurotic edema, cardiac arrest, bronchial asthma, ventricular fibrillation, reduction in bleeding in surgery, cardiopulmonary resuscitation (CPR), local vasoconstrictor to prolong the action of local anesthetic are the indications of adrenaline. Digoxin is indicated for the treatment of mild-to-moderate heart failure. Digoxin is contraindicated in intermittent complete heart block or second-degree atrioventricular block, especially if there is history of Stokes Adams attacks. Digoxin is contraindicated in arrhythmias caused by cardiac glycoside intoxication.