Laxatives are drugs that relieve constipation by loosening stools or inducing a bowel movement. Some laxatives are also used before bowel procedures or examinations. This chapter covers the lactulose, polyethylene glycol, bisacodyl, sucralfate, and sodium picosulfate along with their indication, dose, contraindication, precaution, adverse effect, and drug interaction. Constipation and hepatic encephalopathy are the indications of lactulose. Galactosemia and hypersensitive to drug are the contraindications of lactulose. Constipation and bowel evacuation are the indications of bisacodyl. Hypersensitivity, acute abdomen, abdominal pain, gastroenteritis, rectal bleeding, and appendicitis are the contraindications of bisacodyl.