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Chapter-38 Neuromuscular Blockers/Preanesthetic Medication

BOOK TITLE: Drug Formulary

Author
1. George Mathew
2. Joseph Lincy
3. K Sujith
ISBN
9789352701896
DOI
10.5005/jp/books/14188_39
Edition
1/e
Publishing Year
2018
Pages
7
Author Affiliations
1. Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India
2. Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India
3. Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India
Chapter keywords
Neuromuscular blocker, preanesthetic medication, atracurium, midazolam, succinylcholine, vecuronium, atropine, glycopyrronium, pancuronium

Abstract

Neuromuscular blocking agents produce skeletal muscle paralysis by inhibiting the action of acetylcholine at the neuromuscular junction. Preanesthetic medication is necessary for psychic sedation primarily, to minimize secretions, to fortify impotent anesthetics, and as prophylaxis for suppression of vagal and other autonomic reflex activity. This chapter covers the atracurium, midazolam, succinylcholine, vecuronium, atropine, glycopyrronium, and pancuronium along with their indication, dose, contraindication, precaution, adverse effect, and drug interaction. Depolarizing muscle relaxant, short duration (5 min), rapid, complete, predictable paralysis, and spontaneous recovery are the indications of succinylcholine. Hypersensitivity, severe liver disease, and burns are the contraindications of succinylcholine.

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