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Chapter-39 Neuromuscular Drugs

BOOK TITLE: Drug Formulary

Author
1. George Mathew
2. Joseph Lincy
3. K Sujith
ISBN
9789352701896
DOI
10.5005/jp/books/14188_40
Edition
1/e
Publishing Year
2018
Pages
3
Author Affiliations
1. Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India
2. Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India
3. Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India
Chapter keywords
Neuromuscular-blocking drug, neostigmine, pyridostigmine, tolperisone, cardiac dysrhythmia, gynecological procedure, schizophrenia, myasthenia gravis

Abstract

Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. This chapter covers the neostigmine, pyridostigmine, and tolperisone along with their indication, dose, contraindication, precaution, adverse effect, and drug interaction. Myasthenia gravis, Nardi test, abdominal distension, anticholinergic agent toxicity, cancer pain, cardiac dysrhythmia, gynecological procedure, schizophrenia, myasthenia gravis, neurotoxicity-poisoning due to cobra family snake venom, paroxysmal supraventricular tachycardia, peripheral block anesthesia, postoperative administration of analgesia, urinary retention, pseudo-obstruction of intestine, and regional anesthesia are the indications of neostigmine. Intestinal tract obstruction, mechanical, peritonitis, urinary tract obstruction, and mechanical are the contraindications of neostigmine.

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