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Chapter-07 Nonmotor Symptoms in Parkinson’s Disease

BOOK TITLE: Practice Pearls in Neurology: Series 1

Author
1. Vasudevan D
2. Thaseen A
3. VP Tushar
ISBN
9789352701988
DOI
10.5005/jp/books/14148_8
Edition
1/e
Publishing Year
2018
Pages
5
Author Affiliations
1. Saveetha Medical College, Chennai, Tamil Nadu, India; The Brain, Spine and Nerve Center, Chennai, Tamil Nadu, India
2. Saveetha Medical College, Chennai, Tamil Nadu, India
3. Madras Medical College, Chennai, Tamil Nadu, India
Chapter keywords
Nonmotor symptom, NMS, Parkinson’s disease, PD, nonmotor fluctuation, NMFS, neuropsychiatric symptom, complex behavioral disorder, sensory symptom, sleep disorder, dysautonomia

Abstract

The nonmotor symptoms (NMS) in Parkinson’s disease (PD), though a very prevalent entity is often underreported due to lack of structured history taking by the physician as well as patients and relatives apathy towards these complaints. NMS like pain, urinary symptoms, depression and anxiety is reported in 21% of the patients at the time of presentation, which goes up to 88% after 7 years from disease onset. Involvement of nondopaminergic systems like locus coeruleus, dorsal vagal nucleus, raphe nuclei, hypothalamus, limbic cortex, neocortex are implicated as the cause for NMS in PD. This chapter covers the neuropsychiatric symptoms, complex behavioral disorders, sensory symptoms, sleep disorders, dysautonomia, and nonmotor fluctuations (NMFS).

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