Stress is a natural human response to day-to-day pressure/ changes experienced by an individual. Stress is a natural human response to pressure when faced with challenging and sometimes dangerous situations. At certain level stress-helps a person to improve his efficiency at work. If it exceeds beyond ones tolerance level it may lead to poor coping and other stress-related health problems. Conflict is difficult to define, because it occurs in many different settings. The essence of conflict seems to be disagreement, contradiction, or incompatibility. Frustration is a condition of extreme tension, it is commonly interpreted as strong emotional tension caused by blocking of impulses. This chapter covers the types of stressor, response of body to stressors, sources of stress, models of stress, stress management, types of conflict, and causes of conflict. In this chapter, short essay type questions and multiple choice questions along with their answer key are also provided.