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Chapter-14 Drug and Test Interactions

BOOK TITLE: Use of Progestogens in Clinical Practice of Obstetrics and Gynecology

Author
1. Goel Neerja
2. Jain Sandhya
3. MV Anita
ISBN
9789352702183
DOI
10.5005/jp/books/14146_15
Edition
1/e
Publishing Year
2018
Pages
2
Author Affiliations
1. University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, neerjagoel2002@yahoo.com, University College of Medical Sciences and GTB Hospital, Delhi, India, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India
2. The University College of Medical Sciences (UCMS) and Guru Teg Bahadur (GTB) Hospital, New Delhi, India, University College of Medical Sciences and Guru Teg Bahadur Hospital,Delhi, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, sumeet_singla@indiatimes.com, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India
Chapter keywords
Drug, test interaction, selective serotonin reuptake inhibitor, SSRI, 5α-dihydroprogesterone, 5α-reductase inhibitor, pregnane X receptor, PXR, antifungal agent

Abstract

This chapter describes drug and test interactions. Certain selective serotonin reuptake inhibitors (SSRIs) may increase the GABAA receptor-related central depressant effects of progesterone by enhancing its conversion into 5α-dihydroprogesterone and allopregnanolone via activation of 3α-hydroxysteroid dehydrogenase (3α-HSD). Progesterone potentiates the sedative effects of benzodiazepines and ethanol. 5α-reductase inhibitors, such as finasteride and dutasteride, as well as inhibitors of 3α-HSD, such as medroxyprogesterone acetate, inhibit the conversion of progesterone into its inhibitory neurosteroid metabolites, and for this reason, may have the potential to block or reduce its sedative effects.

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