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Chapter-07 Physiological Actions of Progesterone

BOOK TITLE: Use of Progestogens in Clinical Practice of Obstetrics and Gynecology

Author
1. Goel Neerja
2. Jain Sandhya
3. MV Anita
ISBN
9789352702183
DOI
10.5005/jp/books/14146_8
Edition
1/e
Publishing Year
2018
Pages
3
Author Affiliations
1. University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, neerjagoel2002@yahoo.com, University College of Medical Sciences and GTB Hospital, Delhi, India, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India
2. The University College of Medical Sciences (UCMS) and Guru Teg Bahadur (GTB) Hospital, New Delhi, India, University College of Medical Sciences and Guru Teg Bahadur Hospital,Delhi, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, sumeet_singla@indiatimes.com, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India
Chapter keywords
Progesterone, luteinizing hormone, LH, granulosa cell, menstrual cycle, fetal antigen, endometrium, low density lipoprotein, LDL

Abstract

Progesterone acts through its receptors. The luteinizing hormone (LH) stimulates the receptor expression and receptors begin to appear in the granulosa cells of the dominant follicle in the periovulatory period. Progesterone receptor expression varies in different phases of the menstrual cycle. Progesterone has an important role in mediating the slowing of GnRH pulses in the late luteal phase which causes a rise in FSH necessary for initiating the next cycle. Progesterone prepares and maintains the endometrium to allow implantation of the fertilized zygote. Progesterone is important in preventing maternal rejection of trophoblast by suppressing the maternal immunologic response to fetal antigens.

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