The chapter gives a brief overview on hemostatics, the agents which arrest bleeding. When hemostatic agents are acting locally then they are called styptics. Hemostasis can be achieved by different methods. Hemostasis can be achieved by physical method by pressure application, tourniquet, ligation, cold, and use of cautery. It can also be achieved by using hemostatic agent, which can be local acting agents like tannic acid, thrombin, thromboplastin, fibrin, gelfoam, oxidized cellulose, bone wax, and adrenaline, or can be systemic acting agents like fibrinogen, antihemophilic globulin, plasma or blood, calcium, vitamin and rutin. Vitamin C can control bleeding only in the presence of scurvy. Vitamin K is fat soluble vitamin but is not single entity but occurs naturally in the form of at least two distinct substances, vitamin K1 and K2.