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Chapter-29 Local Drug Delivery

BOOK TITLE: Manual for Dental Hygienist

Author
1. Awasthi Maj Gen PN
ISBN
9789352702282
DOI
10.5005/jp/books/14199_30
Edition
1/e
Publishing Year
2018
Pages
2
Author Affiliations
1. Armed Forces Medical College (AFMC), Pune, Maharashtra, India; Indian Army Dental Corps, Dental Council of India; Manav Rachna Dental College, Faridabad, Haryana, India, Armed Forces Medical College (AFMC), Pune, Maharashtra, India; Indian Army Dental Corps; Dental Council of India; Manav Rachna Dental College, Faridabad, Haryana, India
Chapter keywords
Local drug delivery, local drug delivery system, tetracycline fiber, metronidazole gel, chlorhexidine chip, doxycycline gel, minocycline microsphere

Abstract

Local drug delivery (LDD) is the evolved method of delivering the medication within the gum around the teeth. Its advantages include a controlled method of delivering the drug with a standard dose over an extended period of time. There are five local delivery systems available, namely tetracycline fibers (Actisite, periodontal AB Plus), metronidazole gel (Elyzol), chlorhexidine chip (Periochip), doxycycline gel (Atridox), and minocycline microspheres (Arestin and periocline). Local drug delivery systems are easy to use, achieve high concentration at site, and do not depend on patient compliance. They have fewer side effects and enable reduced resistance incidence. Few disadvantages of local drug delivery systems are that they are expensive, do not kill organisms in nontreated sites, and time consuming if more number of pockets.

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