Chapter-03 Diagnosis: How Sharp Are Our Diagnostic Tools?

BOOK TITLE: FOGSI FOCUS: Prevention of Preterm Labor

1. Garg Ruchika
2. Singh Richa
3. Saravanan Selvapriya
4. Sahetya Raju
5. Gujrathi Nirmal
Publishing Year
Author Affiliations
1. Sarojini Naidu Medical College, Agra, Uttar Pradesh, India
2. Sarojini Naidu Medical College, Agra, Uttar Pradesh,India
3. Fertility and Fetal Medicine Centre, Dr Jeyasekaren Hospital, Kanyakumari, Tamil Nadu, India
4. Hinduja Hospital, Mumbai, Maharashtra, India
5. Cooper Hospital, Thane, Maharashtra, India
Chapter keywords
Preterm labor, preterm birth, biophysical marker, biochemical marker, diagnostic tool, amniotic fluid, intrauterine infection


The aim of this chapter is to focus on the diagnosis of preterm labor. This chapter is divided into three parts, which include predictors of preterm birth, biophysical markers and ultrasound in predicting preterm labor, and role of biochemical markers as diagnostic tools. Preterm labor and birth are a major cause of perinatal morbidity and mortality. Despite modern advances in obstetric and neonatal management, the rate of preterm birth in the developed world is increasing. The discovery of biomarkers that could reliably identify women who will subsequently deliver preterm may allow for timely medical intervention and targeted therapeutic treatments aimed at improving maternal and fetal outcomes. Numbers of biochemical markers in the body fluids such as in the amniotic fluid, urine, cervical mucus, vaginal secretions, and serum or plasma, in saliva have been used in detection of preterm labor.

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