This chapter addresses issue of carcinoma endometrium starting with the case history, examination, and investigations. Pertinent questions related to the issue are given in this chapter along with their crisp and to the point answers. Any bleeding after menopause considered as postmenopausal bleeding (PMB). Menopause is defined as absence of menses for more than one year. 4–11% of postmenopausal women experience postmenopausal bleeding. General physical examination, look for BMI, thyroid swelling, pallor any palpable supraclavicular nodes, per abdominal examination should focus on any palpable mass, organomegaly, fluid per abdomen. Saline infusion sonography is a procedure in which endometrial cavity is distended with sterile saline and TVUS done. It should not be done in patients in whom cancer cells are found in endometrial biopsy due to the risk of spill of cancer cells into the endometrial cavity and upstage the disease. The first line of treatment in endometrial cancer is surgery. Depending on various other factors, the additional treatment options need to be considered. The patient has to follow up 3 monthly for 2 years 6 monthly for 3 years and then annually with clinical examination and imaging.