Written in question and answer format, this chapter presents discussion on diabetes in pregnancy. There are total 71 questions given in this chapter along with their crisp and to the point answers. Due to production of anti-insulin factors by placenta, insulin requirement during pregnancy almost doubles. Those women whose pancreatic reserves are poor, cannot increase the insulin production to the required amount. There are many reasons for glycosuria in pregnancy. They give the urine sugar test positive. Decreased renal threshold, lactosuria, frank diabetes and some times impaired glucose tolerance can causes glycosuria. In case of preterm labor, tocolysis should be with nifedipine. Salbutamol can increase blood sugar. GDM well controlled on diet without any complications can be taken to till 40 weeks. GDM on insulin is usually induced after completed 38 weeks. Insulin analogs are agents structurally similar to insulin produced by substituting or changing the position of one or more aminoacids from the native insulin. They have different pharmacokinetics and different preparations have different onset of action and duration of action.