The pharmacology teaching is undergoing tremendous change and upcoming changes require us to use clinical cases for the learning. The case needs to be designed in a way that it stimulates students to read learning objectives predefined for those sessions. The cases must be developed keeping in view the subject, e.g. cases in pharmacology must focus on learning objectives in pharmacology. The learning activities to be stimulated must be directed to the pharmacotherapeutic aspects of the case. The cases can be live or paper-based cases. The case-based learning (CBL) is being used worldwide in all countries to cover a part of syllabus or for the whole syllabus. The method is commonly used in the business world for learning. The method is reported to be student centered and involves active learning. The students benefit from a number of associated techniques being used in CBL. They become better self-directed learners in starting of their carrier, communication skills improve and decision-making capabilities are developed.