Herpetic keratitis is an infection of cornea caused by the herpes simplex virus (HSV) type 1 or 2. Like many viruses, the HSVs are present in most adults. The viruses in the herpes family usually live around the nerve fibers in humans without ever causing any problem. Occasionally, the viruses will start to multiply, or they will move from one area of the body to another, and that is when herpetic disease breaks out. This often happens when some other disease process significantly weakens the immune system of the body. This chapter describes the common manifestations of herpetic keratitis and its management based on our experiences. HSV is a common cause of corneal infection and one of the leading infectious causes of corneal blindness worldwide. Ocular herpes is typically unilateral. However, bilateral herpetic manifestations have been observed in children and atopic individuals. HSV keratitis has multiple manifestations. The nature of these manifestations is distinctive and can readily be distinguished by careful examination of individual layers of the cornea.