Phacomorphic glaucoma is defined as secondary angle-closure glaucoma due to lens intumescence and is characterized by a sudden rise in intraocular pressure (IOP), which can compromise the function of the optic nerve and may lead to irreversible visual loss if not treated in time. This chapter covers the clinical features, clinical evaluation, mechanism, treatment, phacoemulsification, combined surgery, problems in managing phacomorphic glaucoma, and postoperative regimen. Meticulous postoperative care can improve the visual results even in phacomorphic glaucoma. Potent topical steroids (prednisolone acetate drops 1%) at a frequency of every half to one hourly, with topical antibiotic cover (broad spectrum fourth generation fluoroquinolone) to combat inflammation and prevent infection are imperative.