Stroke is a leading cause of disability and the third leading cause of death. One-third of the strokes occur in patients below the age of 65 years. Stroke, strikes suddenly, with focal neurological deficit like hemiplegia, as a result of a vascular event, an infarct or hemorrhage. Ischemic stroke constitutes 80–85 % of all strokes. This chapter covers the ischemic stroke, MR brain in stroke, intracerebral hemorrhage, lacunar strokes, cerebral venous thrombosis (CVT), and primary subarachnoid hemorrhage. The pathogenesis of ischemic stroke is a large vessel atherosclerotic disease common in carotid, internal carotid, middle cerebral, vertebral and basilar artery. Ischemic stroke can be transient (TIA) which is often underplayed or enduring (completed stroke). MR brain is not a single investigation but has many added imaging techniques—diffusion weighted, and an ADC is necessary to diagnose an acute and subacute infarct.