This chapter describes an overview of women specific issues in diabetes. Men and women experience diabetes mellitus differently in important aspects. Most of the current literature on diabetes mellitus has almost exclusively focused on men and the results of these have been extrapolated to women. This review is a comprehensive effort to integrate the information from these papers with a systematic survey of the literature about the sex specific features of diabetes mellitus. This chapter covers the epidemiology, pathophysiology, diagnosis, diabetic complications, diabetes and menstruation, diabetes and preconception, diabetes and pregnancy, diabetes and postpartum, female sexual dysfunction, diabetes management, and diabetes and menopause. Certain drugs like sodium glucose co-transporter inhibitors are associated with increased incidence of UTI in women with diabetics. Insulin injections are commonly used in women with diabetes and injection through clothing is a common practice among women.