Automation is a self-regulating process, where pipetting of the specimen is accurately done by a mechanical probe and mixed with the particular volume of the reagent. The results are displayed in digital forms after analysis automatically by the instrument. Total quality management is the basis on which clinical laboratories are operated and managed. It has various aspects like quality planning, quality laboratory processing, quality control and quality improvement. The main objective is to have accurate values of all biochemical parameters done in the laboratory.