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Chapter-15 Estimation of Urine Creatinine

BOOK TITLE: An Easy Guide for Practical Biochemistry

Author
1. D’sa Divya Shanthi
2. Lakshmi Sowbhagya
ISBN
9789352702633
DOI
10.5005/jp/books/14203_16
Edition
2/e
Publishing Year
2018
Pages
5
Author Affiliations
1. Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India
2. Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India, Sambhram Institute of Medical Sciences and Research, Kolar, Karnataka, India
Chapter keywords
Urine creatinine, plasma, urine, Jaffe’s alkaline picrate method, creatinine clearance test, renal function test, creatinine coefficient

Abstract

Creatinine is a waste product derived from endogenous sources by tissue creatine breakdown and is excreted by the kidney. Creatinine is the anhydride of creatine. The reaction occurs nonenzymatically. About 98% of the total creatine is in the muscle as creatine phosphate. About 2% of the total creatine is converted daily to creatinine so that the amount of creatinine produced is related to the total muscle mass. Creatinine coefficient is more precise and is used to assess the functional muscle mass in the body. The excretion of creatinine increases in fevers and wasting diseases.

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