This chapter aims to present discussion on general anesthetics. General anesthetics cause reversible loss of sensation and consciousness. Ideal anesthetic provides adequate analgesia and muscle relaxation, should be pleasant, nonirritating, noninflammable. They are classified into inhalational anesthetics and intravenous anesthetics. Inhalational anesthetics are given at a specific concentration. However, for anesthetics with high solubility in blood and tissues, increase in alveolar PP is slower, hence induction is slower. Factors determining anesthetic partial pressure in brain are pulmonary ventilation, partial pressure in inspired gas, alveolar exchange, solubility of anesthetic in blood, solubility of anesthetic in tissues, and cerebral blood flow. Preanesthetic medication, balanced anesthesia, and conscious sedation are also discussed briefly in this chapter.