This chapter describes the relation between religion and science. Science is an unusual phenomenon in human experience: it is rational, but it is based on faith; it is not dogmatic, but it has assumptions; it values authorities, but it is not authoritative; it is organized, but its every member is free; it is an institution, but it doubts everything; it is not an ideology, but it defends its interests; it is not politics, but it makes fateful decisions; it is not law, but it has strict norms. The Orthodox theologian Christos Yannaras, on the other hand, speaking about faith, puts emphasis on the human experience itself, which in its basis is the personal experience of the relation with God. The Orthodox standpoint is present on the issue of the relationship between faith and knowledge, i.e. religion and science. Having in mind everything that had previously been said, we would like to point to two concepts as directives for understanding the Orthodox standpoint on this issue.