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Chapter-12 Choroidal Neovascular Membranes

BOOK TITLE: Retina: Medical and Surgical Management

Author
1. Kumar Atul
2. Sahay Pranita
3. Singh Shilky
4. Brar Anand S
ISBN
9789352702947
DOI
10.5005/jp/books/18054_13
Edition
1/e
Publishing Year
2018
Pages
14
Author Affiliations
1. Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, All India Institute of Medical Sciences, New Delhi, India, Women’s Health Center; Anil Nursing Home, Jaipur, Rajasthan, India, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Jaipur, Rajasthan, India, Dr RP Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Anil Hospital, Jaipur, India, All India Institute of Medical Sciences New Delhi, India, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Dr. RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
2. Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Dr Rajendra Prasad Cenre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, All India Institute of Medical Sciences, New Delhi, India, All India Institute of Medical Sciences (AIIMS), New Delhi, India
3. Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, All India Institute of Medical Sciences New Delhi, India
4. Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, All India Institute of Medical Sciences, New Delhi, India
Chapter keywords
Choroidal neovascular membrane, CNVM, type 1 CNVM, type 2 CNVM, myopic choroid neovascularization, angioid streak, presumed ocular histoplasmosis syndrome, idiopathic choroid neovascularization

Abstract

Choroidal neovascular membrane (CNVM) is characterized by extension of the choriocapillaris through the Bruch’s membrane into subretinal pigment epithelium space (type 1 CNVM) or subretinal space (type 2 CNVM). Recently type 3 CNVM has been recognized as a predominantly intraretinal neovascularization which later extend beneath the retina without a preceding type 1 CNVM. The origin of type 3 CNVM has been proposed to be from deep retinal capillary plexus which develops early retinochoroidal anastomosis (RCA) or from the choriocapillaris. The two basic prerequisites for the formation of CNVM are proliferation of the choriocapillaris and compromised Bruch’s membrane and/or retinal pigment epithelium (RPE) function. Currently, ranibizumab is the only Food and Drug Administration (FDA) approved drug for myopic CNV. A detailed discussion on choroid neovascularization postchoroidal rupture, angioid streaks, and presumed ocular histoplasmosis syndrome has been provided in this chapter.

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