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BOOK TITLE: Retina: Medical and Surgical Management
Choroidal neovascular membrane (CNVM) is characterized by extension of the choriocapillaris through the Bruch’s membrane into subretinal pigment epithelium space (type 1 CNVM) or subretinal space (type 2 CNVM). Recently type 3 CNVM has been recognized as a predominantly intraretinal neovascularization which later extend beneath the retina without a preceding type 1 CNVM. The origin of type 3 CNVM has been proposed to be from deep retinal capillary plexus which develops early retinochoroidal anastomosis (RCA) or from the choriocapillaris. The two basic prerequisites for the formation of CNVM are proliferation of the choriocapillaris and compromised Bruch’s membrane and/or retinal pigment epithelium (RPE) function. Currently, ranibizumab is the only Food and Drug Administration (FDA) approved drug for myopic CNV. A detailed discussion on choroid neovascularization postchoroidal rupture, angioid streaks, and presumed ocular histoplasmosis syndrome has been provided in this chapter.