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BOOK TITLE: Retina: Medical and Surgical Management
The chapter retinopathy in hematological disorders is divided into two parts, i.e. leukemic retinopathy and sickle cell retinopathy. Leukemia is a group of neoplastic disorders that usually begin in the bone marrow and result in high numbers of abnormal white blood cells. Leukemia may be broadly divided into B cell or T cell, or leucoid or myeloid type, according to the cell of origin. The mainstay of leukemia therapy is systemic chemotherapy. Ocular manifestations usually do not require direct treatment. Intrathecal chemotherapy is also done in addition to intravenous therapy for patients who have CNS involvement as well. Cranial irradiation may also be done to support chemotherapy. Retinopathy associated with systemic disorder of sickle cell disease (SCD), which is a group of hemoglobinopathies characterized by intravascular hemolysis and defective oxygen transport by red blood cells. Prevalence, pathophysiology, systemic manifestations, ophthalmic manifestations, nonproliferative sickle retinopathy, proliferative sickle retinopathy, natural history, imaging, ophthalmic treatments, and systemic therapy of sickle cell disease are also discussed in this chapter.
Sandra Frazier Byrne, Ronald l. Green
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AK Khurana, Aruj K Khurana
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PK Mukherjee
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