Despite good progress in the management of patients with atrial fibrillation (AF), this arrhythmia remains one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity in the world. Its prevalence is more in patients with conditions such as hypertension, heart failure, coronary artery disease (CAD), valvular heart disease, obesity, diabetes mellitus, and chronic kidney disease (CKD). The increase in AF prevalence can be attributed both to better detection of silent AF, along with increasing age and conditions predisposing to AF. This chapter covers the overt and silent atrial fibrillation, patients with atrial fibrillation and heart failure with reduced ejection fraction, and integrated management of patients with atrial fibrillation in anticoagulated patients.