This chapter describes the role of nurses in a structured manner for cardiac rehabilitation in cardiodiabetes. In most developed countries worldwide, the number of patients with chronic heart failure is growing, with 1–3% of the adult population suffering from this syndrome, rising to about 10% in the very elderly. Diabetes mellitus (DM) is increasing in prevalence in the United States and is now more common in patients entering cardiac rehabilitation (CR). The association between DM and cardiovascular disease is well established, and diabetic patients who have suffered with myocardial infarction (MI) have worse outcomes than no diabetics. This chapter covers the phases of rehabilitation following acute coronary syndrome, factors associated with cardiovascular disease, and general precautions for patients with diabetes.