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Chapter-068 Bisoprolol: A Choice of Beta Blocker in Hypertension and ACS in Cardiodiabetes

BOOK TITLE: Cardiodiabetes Update: A Textbook of Cardiology

Author
1. Manjunath CN
2. Prabhavathi
ISBN
9789352703043
DOI
10.5005/jp/books/14130_69
Edition
1/e
Publishing Year
2018
Pages
6
Author Affiliations
1. Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, India, Sri Jayadeva Institute of Cardiovascular, Sciences and Research, Bengaluru, Karnataka, India, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, India, Sri Jayadeva Institute of Cardiovascular Sciences and Research Bengaluru, Karnataka, India
2. Sri Jayadeva Institute of Cardiovascular, Sciences and Research, Bengaluru, Karnataka, India, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, India
Chapter keywords
Beta blocker, BB, myocardial infarction, MI, hypertension, acute coronary syndrome, ACS, left ventricular, LV, bisoprolol, heart failure

Abstract

Beta blocker therapy is recommended as part of the emergency treatment of suspected acute coronary syndrome (ACS), especially if the patient has tachycardia or hypertension. The benefit is even more in patients with left ventricular (LV) dysfunction. Hypertension guidelines recommend use of beta blockers in hypertension with compelling indications, such as heart failure, postmyocardial infarction (MI), high-risk for coronary disease, and diabetes. Bisoprolol is a highly selective beta-1 adrenoceptor antagonist. It has no partial agonist (intrinsic sympathomimetic) activity or membrane stabilizing (local anesthetic) activity. Oral bioavailability of bisoprolol is high (90%) and the drug has a long elimination half-life of 10–12 hours, which allows once daily administration. Bisoprolol has been found to be beneficial in treatment of angina pectoris in patients with chronic obstructive bronchitis without an increased risk of clinically significant deterioration.

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