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Chapter-093 Benidipine: A New Calcium Channel Blocker for Management of Hypertension and Angina in Cardiodiabetes

BOOK TITLE: Cardiodiabetes Update: A Textbook of Cardiology

Author

1. Ponde CK
2. Parekh Maulik

ISBN

9789352703043

DOI

10.5005/jp/books/14130_94

Edition

1/e

Publishing Year

2018

Pages

Author Affiliations

1. PD Hinduja National Hospital and MRC, Mumbai, Maharashtra, India, PD Hinduja National Hospital and MRC Hinduja Healthcare Surgical, Mumbai, Maharashtra, India, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India, PD Hinduja Hospital, Mumbai, Maharashtra, India, PD Hinduja National Hospital and MRC, Mahim Hinduja Healthcare Surgical Kar, Mumbai, Maharashtra, India, PD Hinduja National Hospital, Mumbai, Maharashtra, India, PD Hinduja Hospital, Mahim, Mumbai, Maharashtra, India
2. PD Hinduja National Hospital, Mumbai, Maharashtra, India, Parmanand Deepchand Hinduja National Hospital, Mumbai, Maharashtra, India, PD Hinduja Hospital, Mumbai, Maharashtra, India, Sir HN Reliance Foundation Hospital, Mumbai, Maharashtra, India

Chapter keywords

Benidipine, hypertension, cardiodiabetes, calcium channel blocker, CCB, low-density lipoprotein, LDL, pharmacokinetic, amlodipine

Abstract

Abstract

Benidipine is triple calcium channel blocker (CCB) with long duration of action and membrane selective binding. It has vascular protecting qualities namely NO production, prevention of oxidation of LDL and suppression of aldosterone production. It has 19 times more vascular selectivity than amlodipine and is twice as potent as amlodipine for hypertension control. Benidipine hydrochloride is a racemic mixture of two isomers (S and R), and odorless to slightly yellowish crystalline powder which is stable under varying light conditions and does not decompose even in high humidity. This chapter covers the pharmacokinetics of benidipine, clinical evidences with benidipine, and comparison with other calcium channel blockers.

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