Cardiovascular diseases (CVD), comprising coronary heart (CHD) and cerebrovascular diseases, are currently the leading cause of death globally, accounting for 21.9% of total deaths, and are projected to increase to 26.3% by 2030. Glycemic and CVD risk factors control can be challenging in any context, not least in the subcontinent. Evidence-based recommendations for diabetes care, mainly based on trials in Anglo-Caucasian populations, are available, but there is no indication of how well these guidelines are not implemented in South Asia, nor is any randomized trial evidence available from this particular population group. The Diabetes Collaborative Registry (DCR) has been designed to track and improve the quality of care of diabetes and metabolic syndrome across the continuum of primary and specialty care. The participation of primary care physicians, endocrinologists, cardiologists, and other healthcare providers managing diabetes is encouraged.