The objective of this chapter is to introduce the anxiolytics. Benzodiazepines are the most frequently prescribed anxiolytic agents. Buspirone a 5HT1A serotonin agonist with some dopaminergic effects is also a useful anti-anxiety agent. Anticonvulsants like gabapentin and pregabalin or antidepressants are often common adjuncts in treating some anxiety states. This chapter covers the indications of use of benzodiazepines, indications of use of buspirone, adverse effect of buspirone, and advantages of buspirone. Indications of use of benzodiazepines are generalized anxiety disorders, panic disorders (alprazolam), muscle relaxation for increased muscle tension, and myoclonic epilepsy (clonazepam). Indications for use of buspirone are social phobia, mixed anxiety with depression, and anxiety associated with substance abuse.