This chapter focuses on general neurological assessment. Case history include history of presenting condition, information about vertigo, information about mental symptom, and information about disturbance in sleep rhythm. Diabetes, blood pressure, cardiac disease, and orthopedic dysfunction are the associated problems. General appearance during pain assessment shows agitation, vomitus, and urinary or fecal incontinence. A detailed description on pain assessment during observation, palpation, and examination has been provided in this chapter.